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Drug and Alcohol Dependence Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions.

This is clearly in line with Article 16.3 of the Convention which states that: “Each Party shall endeavour to prohibit the sale of cigarettes individually or in small packets which increase the affordability of such products to minors.” Regretfully, it is observed in these past few weeks that there has been pressure on the Government to bring back the sale of kiddie packs to combat the increasing sale of illicit cigarettes. The adoption of this possible undesirable action is a clear violation of the FCTC Article 5.3 where public health policies on tobacco control are being challenged by entities of commercial and vested interest. NCWO is of the view that the Government should not be put under such pressure for the following reasons. 1. The evidence is staggering; tobacco kills one person every six seconds – that is, one in 10 deaths among adults worldwide – and accounts for 500 million deaths a year. By 2030, unless urgent action is taken, tobacco’s annual death toll will rise to more than eight million. WHO in its Global Tobacco Epidemic Report 2008 warns us that if current trends continue unchecked, tobacco could kill up to one billion people in this century. 2. Every day, 50 teenagers in Malaysia begin smoking.

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